{"id":254,"date":"2024-12-11T10:34:13","date_gmt":"2024-12-11T10:34:13","guid":{"rendered":"https:\/\/cabbarkartal.com\/hot-chemotherapy-hipek\/"},"modified":"2026-11-13T22:33:04","modified_gmt":"2026-11-13T22:33:04","slug":"hot-chemotherapy-hipek","status":"publish","type":"page","link":"https:\/\/cabbarkartal.com\/en\/hot-chemotherapy-hipek\/","title":{"rendered":"Hot Chemotherapy (Hipek)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"254\" class=\"elementor elementor-254 elementor-84\" data-elementor-post-type=\"page\">\n\t\t\t\t<section class=\"elementor-element elementor-element-s254hero e-flex e-con-boxed e-con e-parent\" data-id=\"s254hero\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-s254hl e-flex e-con-full e-con e-parent\" data-id=\"s254hl\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-s254bc elementor-widget elementor-widget-html\" data-id=\"s254bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<nav aria-label=\"Breadcrumb\" style=\"font-size:13px;color:#52657A;\"><a href=\"\/en\/\" style=\"color:#154B82;font-weight:600;text-decoration:none;\">Home<\/a> <span style=\"margin:0 6px;\">\/<\/span> <a href=\"\/en\/treatments\/\" style=\"color:#154B82;font-weight:600;text-decoration:none;\">Treatments<\/a> <span style=\"margin:0 6px;\">\/<\/span> <span>Hot Chemotherapy (HIPEC)<\/span><\/nav>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-s254eye elementor-widget elementor-widget-html\" data-id=\"s254eye\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<span class=\"ck-eyebrow\">SURGICAL ONCOLOGY \u00b7 PERITONEAL SURFACE MALIGNANCIES<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-s254h1 elementor-widget elementor-widget-heading\" data-id=\"s254h1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Hot Chemotherapy (HIPEC)<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-s254lead elementor-widget elementor-widget-text-editor\" data-id=\"s254lead\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Cytoreductive surgery followed by heated intraperitoneal chemotherapy (40\u201342\u00b0C) delivered directly into the abdominal cavity for eligible peritoneal cancer patients.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-s254ctas elementor-widget elementor-widget-html\" data-id=\"s254ctas\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div style=\"display:flex;flex-wrap:wrap;gap:12px;margin:4px 0 12px;\"><a class=\"ck-btn-cobalt\" href=\"\/en\/contact\/\">Book Appointment \u2192<\/a><a class=\"ck-btn-wa\" href=\"https:\/\/wa.me\/905331492543\" target=\"_blank\" rel=\"noopener\">Ask via WhatsApp<\/a><\/div><p style=\"margin:0;padding-top:12px;border-top:1px solid #D3DFEC;font-size:13.5px;color:#52657A;\"><strong style=\"color:#0E1B2A;\">Surgeon:<\/strong> Prof. Abdulcabbar Kartal, MD (FEBS-C) &nbsp;\u00b7&nbsp; <strong style=\"color:#0E1B2A;\">Hospital:<\/strong> Anadolu Medical Center (Gebze)<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-s254hr e-flex e-con-full e-con e-parent\" data-id=\"s254hr\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-s254sum elementor-widget elementor-widget-html\" data-id=\"s254sum\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div style=\"font-family:'Newsreader',Georgia,serif;font-size:20px;font-weight:600;color:#0E1B2A;margin:0 0 6px;\">Clinical Protocol Overview<\/div><div style=\"padding:10px 0;border-bottom:1px solid #E6EDF5;\"><div style=\"font-size:11.5px;font-weight:700;letter-spacing:0.05em;text-transform:uppercase;color:#154B82;margin-bottom:3px;\">Procedure<\/div><div style=\"font-size:14px;line-height:1.5;color:#364659;\">Cytoreductive Surgery + Hyperthermic Intraperitoneal Chemotherapy<\/div><\/div><div style=\"padding:10px 0;border-bottom:1px solid #E6EDF5;\"><div style=\"font-size:11.5px;font-weight:700;letter-spacing:0.05em;text-transform:uppercase;color:#154B82;margin-bottom:3px;\">Temperature &amp; Duration<\/div><div style=\"font-size:14px;line-height:1.5;color:#364659;\">40\u201342\u00b0C controlled circulation for 60\u201390 minutes<\/div><\/div><div style=\"padding:10px 0;border-bottom:1px solid #E6EDF5;\"><div style=\"font-size:11.5px;font-weight:700;letter-spacing:0.05em;text-transform:uppercase;color:#154B82;margin-bottom:3px;\">Typical Hospital Stay<\/div><div style=\"font-size:14px;line-height:1.5;color:#364659;\">10\u201314 days of inpatient post-operative monitoring<\/div><\/div><div style=\"padding:10px 0;border-bottom:1px solid #E6EDF5;\"><div style=\"font-size:11.5px;font-weight:700;letter-spacing:0.05em;text-transform:uppercase;color:#154B82;margin-bottom:3px;\">Patient Selection<\/div><div style=\"font-size:14px;line-height:1.5;color:#364659;\">Multidisciplinary oncology evaluation of disease extent &amp; fitness<\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/section>\n\t\t<section class=\"elementor-element elementor-element-s254body e-flex e-con-boxed e-con e-parent\" data-id=\"s254body\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-s254prosecol e-flex e-con-full e-con e-parent\" data-id=\"s254prosecol\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-s254prose elementor-widget elementor-widget-html\" data-id=\"s254prose\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ck-clinical-prose\">\n<p>Hot Chemotherapy (Hipek) is an advanced method used to treat types of cancer in the abdominal cavity. Hipek involves the delivery of heated chemotherapy drugs directly into the abdominal cavity in a device outside the body, which is administered following surgery. This innovative method often provides an effective treatment option for peritoneal cancers.<\/p>\n<h2>Definition and Objectives of Hot Chemotherapy (Hipek)<\/h2>\nHipek stands for \"Hyperthermic Intraperitoneal Chemotherapy\". This treatment method, administered during surgery, aims to \n<ol>\n \t<li>To destroy microscopic cancer cells in the abdomen.<\/li>\n \t<li>Enabling chemotherapy drugs to reach tumor cells directly.<\/li>\n \t<li>Reducing the side effects of chemotherapy so that less drug enters the systemic circulation.<\/li>\n<\/ol>\n<h3>In Which Situations is Hipek Applied?<\/h3>\nHipek is usually used for the following types of cancer:\n<ul>\n \t<li>Peritoneal carcinomatosis (cancer that has spread to the peritoneum)<\/li>\n \t<li>Ovarian cancers<\/li>\n \t<li>Stomach cancers that have spread to the peritoneum<\/li>\n \t<li>Advanced stages of colorectal cancer<\/li>\n \t<li>Pseudomyxoma peritonei (a rare intra-abdominal tumor)<\/li>\n<\/ul>\n<h3>How is Hot Chemotherapy (Hipek) Administered?<\/h3>\n<ol>\n \t<li><strong>Surgical Resection:<\/strong>\n<ul>\n \t<li>Before starting the Hipek procedure, the tumorous tissues are surgically removed. This stage is called cytoreductive surgery. <\/li>\n<\/ul>\n<\/li>\n \t<li><strong>Chemotherapy Preparation:<\/strong>\n<ul>\n \t<li>Chemotherapy drugs are heated so that the intra-abdominal temperature remains constant between 40-42\u00b0C.<\/li>\n<\/ul>\n<\/li>\n \t<li><strong>Administration of Chemotherapy:<\/strong>\n<ul>\n \t<li>Warm chemotherapy fluid is pumped into the abdominal cavity and circulated for about 60-90 minutes. During this time, a high concentration of drugs reaches the cancer cells. <\/li>\n<\/ul>\n<\/li>\n \t<li><strong>Termination<\/strong>\n<ul>\n \t<li>After the procedure is completed, the chemotherapy fluid is drained and the surgical procedure is terminated.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<h3>Advantages of Hipek<\/h3>\n<ul>\n \t<li><strong>Direct Effect:<\/strong> Chemotherapy drugs reach cancer cells directly.<\/li>\n \t<li><strong>Reduced Side Effects:<\/strong> Serious side effects seen with systemic chemotherapy are minimized with Hipek.<\/li>\n \t<li><strong>Improved Survival Times:<\/strong> Potential to prolong life in eligible patients.<\/li>\n<\/ul>\n<h3>Disadvantages and Risks of Hipek<\/h3>\n<ul>\n \t<li><strong>Surgical Risks:<\/strong> Hipek is performed in conjunction with major surgery and complications from surgery can occur.<\/li>\n \t<li><strong>Recovery Period:<\/strong> The patient may have a long recovery period after surgery.<\/li>\n \t<li><strong>Limited Eligibility:<\/strong> Not all patients may be suitable for this treatment; selection needs to be made carefully.<\/li>\n<\/ul>\n<h3>Suitability for Hipek Therapy<\/h3>\nThe success of Hipek treatment depends on the patient's general health and the extent to which the cancer has spread. Patients eligible for Hipek are usually: \n<ul>\n \t<li>In cases where the cancer is localized,<\/li>\n \t<li>Individuals in good general health.<\/li>\n<\/ul>\n<h3>Recovery Process After Hipek<\/h3>\n<ul>\n \t<li><strong>Length of Hospitalization:<\/strong> The duration of hospitalization after hyphex is usually 10-14 days.<\/li>\n \t<li><strong>Diet and Nutrition:<\/strong> Bowel movements are expected to return to normal after surgery.<\/li>\n \t<li><strong>Regular Follow-up:<\/strong> Regular post-treatment check-ups are important to monitor the progression of the disease.<\/li>\n<\/ul>\n<h3>Differences between Hipek and Traditional Chemotherapy<\/h3>\n<div class=\"ck-table-scroll\"><table>\n<thead>\n<tr>\n<th><strong>Feature<\/strong><\/th>\n<th><strong>Hipek<\/strong><\/th>\n<th><strong>Traditional Chemotherapy<\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Mode of Application<\/strong><\/td>\n<td>Intra-abdominal administration of hot medication<\/td>\n<td>Systemic administration via intravenous route<\/td>\n<\/tr>\n<tr>\n<td><strong>Side Effects<\/strong><\/td>\n<td>Fewer systemic side effects<\/td>\n<td>Side effects felt throughout the body<\/td>\n<\/tr>\n<tr>\n<td><strong>Impact Area<\/strong><\/td>\n<td>Locally focused on intra-abdominal cancer cells<\/td>\n<td>Cancer cells scattered throughout the body<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<h3>Hipek's Success Rate<\/h3>\nHipek's success rates depend on the type and stage of cancer. Patients diagnosed at an early stage and treated with Hipek can have significantly longer life expectancy.\n\nHipek is an effective and innovative method in cancer treatment. In appropriate patients, it can improve quality of life and prolong survival. However, this treatment should be performed by a specialized team and experienced surgeons. If you want to know more about the treatment of Hypek, you can consult a specialist doctor and evaluate the appropriate treatment options.\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-s254asidecol e-flex e-con-full e-con e-parent\" data-id=\"s254asidecol\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-s254aside elementor-widget elementor-widget-html\" data-id=\"s254aside\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ck-aside-card\" style=\"margin-bottom:20px;\">\n  <div class=\"ck-aside-doc\">\n    <img loading=\"lazy\" src=\"https:\/\/cabbarkartal.com\/wp-content\/uploads\/2026\/11\/prof-dr-abdulcabbar-kartal-portre.jpg\" alt=\"Prof. Abdulcabbar Kartal, MD\" width=\"64\" height=\"78\" loading=\"lazy\" decoding=\"async\" \/>\n    <div>\n      <strong style=\"display:block;font-size:15.5px;color:#0E1B2A;\">Prof. Abdulcabbar Kartal, MD<\/strong>\n      <span style=\"font-size:12.5px;color:#52657A;line-height:1.4;display:block;margin-top:2px;\">General Surgery &amp; FEBS-C Coloproctology<\/span>\n    <\/div>\n  <\/div>\n  <p style=\"font-size:13.5px;line-height:1.6;color:#364659;margin:0 0 14px;\">Share prior colonoscopy, pathology, or MRI\/CT reports to schedule a consultation or second opinion.<\/p>\n  <div style=\"display:grid;gap:10px;\">\n    <a class=\"ck-btn-wa\" href=\"https:\/\/wa.me\/905331492543\" target=\"_blank\" rel=\"noopener\" style=\"width:100%;\">Send Reports via WhatsApp<\/a>\n    <a class=\"ck-btn-outline\" href=\"tel:+905331492543\" style=\"width:100%;\">+90 533 149 25 43<\/a>\n  <\/div>\n<\/div>\n<div class=\"ck-aside-card\">\n  <div style=\"font-size:11.5px;font-weight:700;letter-spacing:0.07em;text-transform:uppercase;color:#52657A;margin-bottom:10px;\">All Specialties<\/div>\n  <div class=\"ck-aside-list\">\n    <a href=\"\/en\/colorectal-surgery-large-intestine-cancers\/\" class=\"\"><span>Colorectal Surgery (Colon Cancer)<\/span><span>\u2192<\/span><\/a>\n<a href=\"\/en\/hot-chemotherapy-hipek\/\" class=\"is-current\"><span>Hot Chemotherapy (HIPEC)<\/span><span>\u2192<\/span><\/a>\n<a href=\"\/en\/hemorrhoidal-disease-hemorrhoids\/\" class=\"\"><span>Hemorrhoidal Disease (Hemorrhoids)<\/span><span>\u2192<\/span><\/a>\n<a href=\"\/en\/anal-fissure\/\" class=\"\"><span>Anal Fissure<\/span><span>\u2192<\/span><\/a>\n  <\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/section>\n\t\t<section class=\"elementor-element elementor-element-s254cta e-flex e-con-boxed e-con e-parent\" data-id=\"s254cta\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-s254ctah elementor-widget elementor-widget-html\" data-id=\"s254ctah\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:space-between;gap:28px;\">\n  <div style=\"max-width:660px;\">\n    <span style=\"display:inline-block;padding:5px 10px;border-radius:4px;background:rgba(255,255,255,0.12);color:#E2ECF7;font-size:11.5px;font-weight:700;letter-spacing:0.06em;text-transform:uppercase;margin-bottom:12px;\">Direct Access &amp; Appointments<\/span>\n    <h2 style=\"font-family:'Newsreader',Georgia,serif;font-size:clamp(26px,3.2vw,36px);font-weight:600;line-height:1.18;color:#FFFFFF;margin:0 0 10px;\">Schedule an examination or request a second opinion<\/h2>\n    <p style=\"font-size:15.5px;line-height:1.65;color:#CBD8E6;margin:0;\">Share your medical reports or arrange an in-person consultation with Prof. Abdulcabbar Kartal, MD at Anadolu Medical Center (Gebze \/ Kocaeli).<\/p>\n  <\/div>\n  <div style=\"display:flex;flex-wrap:wrap;gap:12px;\">\n    <a class=\"ck-btn-wa\" href=\"https:\/\/wa.me\/905331492543\" target=\"_blank\" rel=\"noopener\">Message on WhatsApp<\/a>\n    <a class=\"ck-btn-cobalt\" href=\"\/en\/contact\/\" style=\"background:#FFFFFF;color:#0E1B2A !important;border-color:#FFFFFF;\">Appointment Form \u2192<\/a>\n    <a class=\"ck-btn-outline\" href=\"tel:+905331492543\" style=\"background:transparent;color:#FFFFFF !important;border-color:rgba(255,255,255,0.35);\">+90 533 149 25 43<\/a>\n  <\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Home \/ Treatments \/ Hot Chemotherapy (HIPEC) SURGICAL ONCOLOGY \u00b7 PERITONEAL SURFACE MALIGNANCIES Hot Chemotherapy (HIPEC) Cytoreductive surgery followed by heated intraperitoneal chemotherapy (40\u201342\u00b0C) delivered directly into the abdominal cavity for eligible peritoneal cancer patients. Book Appointment \u2192Ask via WhatsApp Surgeon: Prof. Abdulcabbar Kartal, MD (FEBS-C) &nbsp;\u00b7&nbsp; Hospital: Anadolu Medical Center (Gebze) Clinical Protocol OverviewProcedureCytoreductive [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-254","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cabbarkartal.com\/en\/wp-json\/wp\/v2\/pages\/254","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cabbarkartal.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cabbarkartal.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cabbarkartal.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cabbarkartal.com\/en\/wp-json\/wp\/v2\/comments?post=254"}],"version-history":[{"count":2,"href":"https:\/\/cabbarkartal.com\/en\/wp-json\/wp\/v2\/pages\/254\/revisions"}],"predecessor-version":[{"id":488,"href":"https:\/\/cabbarkartal.com\/en\/wp-json\/wp\/v2\/pages\/254\/revisions\/488"}],"wp:attachment":[{"href":"https:\/\/cabbarkartal.com\/en\/wp-json\/wp\/v2\/media?parent=254"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}